2ki0

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NMR Structure of a de novo designed beta alpha betaNMR Structure of a de novo designed beta alpha beta

Structural highlights

2ki0 is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

A designer monomeric protein with a beta alpha beta fold--two parallel beta strands connected by an alpha helix (see structure)--was constructed solely from coded amino acids. The high thermal stability of the structure is due to a large extent to tryptophan-tryptophan interactions between the two beta strands.

De novo design of a beta alpha beta motif.,Liang H, Chen H, Fan K, Wei P, Guo X, Jin C, Zeng C, Tang C, Lai L Angew Chem Int Ed Engl. 2009;48(18):3301-3. PMID:19347908[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. Liang H, Chen H, Fan K, Wei P, Guo X, Jin C, Zeng C, Tang C, Lai L. De novo design of a beta alpha beta motif. Angew Chem Int Ed Engl. 2009;48(18):3301-3. PMID:19347908 doi:10.1002/anie.200805476
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