2igp

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Crystal Structure of Hec1 CH domainCrystal Structure of Hec1 CH domain

Structural highlights

2igp is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NDC80_HUMAN Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.[1] [2] [3] [4] [5] [6] [7] [8] [9]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Chen Y, Riley DJ, Chen PL, Lee WH. HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis. Mol Cell Biol. 1997 Oct;17(10):6049-56. PMID:9315664
  2. ↑ Martin-Lluesma S, Stucke VM, Nigg EA. Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science. 2002 Sep 27;297(5590):2267-70. PMID:12351790 doi:http://dx.doi.org/10.1126/science.1075596
  3. ↑ DeLuca JG, Howell BJ, Canman JC, Hickey JM, Fang G, Salmon ED. Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores. Curr Biol. 2003 Dec 2;13(23):2103-9. PMID:14654001
  4. ↑ Stucke VM, Baumann C, Nigg EA. Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. Chromosoma. 2004 Aug;113(1):1-15. Epub 2004 Jul 3. PMID:15235793 doi:http://dx.doi.org/10.1007/s00412-004-0288-2
  5. ↑ Joseph J, Liu ST, Jablonski SA, Yen TJ, Dasso M. The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo. Curr Biol. 2004 Apr 6;14(7):611-7. PMID:15062103 doi:http://dx.doi.org/10.1016/j.cub.2004.03.031
  6. ↑ Meraldi P, Draviam VM, Sorger PK. Timing and checkpoints in the regulation of mitotic progression. Dev Cell. 2004 Jul;7(1):45-60. PMID:15239953 doi:http://dx.doi.org/10.1016/j.devcel.2004.06.006
  7. ↑ Bharadwaj R, Qi W, Yu H. Identification of two novel components of the human NDC80 kinetochore complex. J Biol Chem. 2004 Mar 26;279(13):13076-85. Epub 2003 Dec 29. PMID:14699129 doi:http://dx.doi.org/10.1074/jbc.M310224200
  8. ↑ DeLuca JG, Dong Y, Hergert P, Strauss J, Hickey JM, Salmon ED, McEwen BF. Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. Mol Biol Cell. 2005 Feb;16(2):519-31. Epub 2004 Nov 17. PMID:15548592 doi:http://dx.doi.org/10.1091/mbc.E04-09-0852
  9. ↑ Lin YT, Chen Y, Wu G, Lee WH. Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. Oncogene. 2006 Nov 2;25(52):6901-14. Epub 2006 May 29. PMID:16732327 doi:http://dx.doi.org/1209687

2igp, resolution 1.80Å

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