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Crystal structure of Aquifex aeolicus TilS in a complex with ATP, Magnesium ion, and L-lysineCrystal structure of Aquifex aeolicus TilS in a complex with ATP, Magnesium ion, and L-lysine
Structural highlights
FunctionTILS_AQUAE Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity). Evolutionary Conservation![]() Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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