2e44

Solution structure of RNA binding domain in Insulin-like growth factor 2 mRNA binding protein 3Solution structure of RNA binding domain in Insulin-like growth factor 2 mRNA binding protein 3

Structural highlights 2e44 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN Function IF2B3_HUMAN RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Insulin-like growth factor 2 mRNA-binding protein

spinqualitylabelsall models 2e44 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image