2d1x

The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complexThe crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex

Structural highlights

2d1x is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SRC8_HUMAN Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ von Holleben M, Gohla A, Janssen KP, Iritani BM, Beer-Hammer S. Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading. J Biol Chem. 2011 Apr 15;286(15):13489-501. doi: 10.1074/jbc.M110.155184. Epub, 2011 Feb 4. PMID:21296879 doi:http://dx.doi.org/10.1074/jbc.M110.155184
↑ Hashimoto S, Hirose M, Hashimoto A, Morishige M, Yamada A, Hosaka H, Akagi K, Ogawa E, Oneyama C, Agatsuma T, Okada M, Kobayashi H, Wada H, Nakano H, Ikegami T, Nakagawa A, Sabe H. Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7036-41. Epub 2006 Apr 24. PMID:16636290

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OCA

[1] von Holleben M, Gohla A, Janssen KP, Iritani BM, Beer-Hammer S. Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading. J Biol Chem. 2011 Apr 15;286(15):13489-501. doi: 10.1074/jbc.M110.155184. Epub, 2011 Feb 4. PMID:21296879 doi:http://dx.doi.org/10.1074/jbc.M110.155184

[2] Hashimoto S, Hirose M, Hashimoto A, Morishige M, Yamada A, Hosaka H, Akagi K, Ogawa E, Oneyama C, Agatsuma T, Okada M, Kobayashi H, Wada H, Nakano H, Ikegami T, Nakagawa A, Sabe H. Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7036-41. Epub 2006 Apr 24. PMID:16636290

[1]

[2]

2d1x

The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complexThe crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex

Structural highlights

Function

Evolutionary Conservation

References

Contents

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2d1x

The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complexThe crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex

Structural highlights

Function

Evolutionary Conservation

References

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