2cod

Solution structure of the N-terminal PH domain of ARAP2 protein from humanSolution structure of the N-terminal PH domain of ARAP2 protein from human

Structural highlights

2cod is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

ARAP2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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OCA

2cod

Solution structure of the N-terminal PH domain of ARAP2 protein from humanSolution structure of the N-terminal PH domain of ARAP2 protein from human

Structural highlights

Function

Evolutionary Conservation

Contents

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2cod

Solution structure of the N-terminal PH domain of ARAP2 protein from humanSolution structure of the N-terminal PH domain of ARAP2 protein from human

Structural highlights

Function

Evolutionary Conservation

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