2bbz

Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP InhibitionCrystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition

Structural highlights

2bbz is a 4 chain structure with sequence from Molluscum contagiosum virus subtype 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.8Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CFLA_MCV1 Inhibits TNFRSF1A, TNFRSF6 and TNFRSF12 induced apoptosis. May interfere with caspase-8 recruitment and activation at the death-inducing signaling complex (DISC). May lead to higher virus production and contribute to virus persistence and oncogenicity.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Thome M, Schneider P, Hofmann K, Fickenscher H, Meinl E, Neipel F, Mattmann C, Burns K, Bodmer JL, Schroter M, Scaffidi C, Krammer PH, Peter ME, Tschopp J. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature. 1997 Apr 3;386(6624):517-21. PMID:9087414 doi:http://dx.doi.org/10.1038/386517a0
↑ Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, Banks S, Wang GH, Senkevich TG, Alnemri ES, Moss B, Lenardo MJ, Tomaselli KJ, Cohen JI. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1172-6. PMID:9037025

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OCA

[1] Thome M, Schneider P, Hofmann K, Fickenscher H, Meinl E, Neipel F, Mattmann C, Burns K, Bodmer JL, Schroter M, Scaffidi C, Krammer PH, Peter ME, Tschopp J. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature. 1997 Apr 3;386(6624):517-21. PMID:9087414 doi:http://dx.doi.org/10.1038/386517a0

[2] Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, Banks S, Wang GH, Senkevich TG, Alnemri ES, Moss B, Lenardo MJ, Tomaselli KJ, Cohen JI. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1172-6. PMID:9037025

[1]

[2]

2bbz

Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP InhibitionCrystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition

Structural highlights

Function

Evolutionary Conservation

References

Contents

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2bbz

Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP InhibitionCrystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition

Structural highlights

Function

Evolutionary Conservation

References

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