2a2c

x-ray structure of human N-acetyl galactosamine kinase complexed with Mg-ADP and N-acetyl galactosamine 1-phosphatex-ray structure of human N-acetyl galactosamine kinase complexed with Mg-ADP and N-acetyl galactosamine 1-phosphate

Structural highlights

2a2c is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.65Å
Ligands:	, , , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GALK2_HUMAN Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Pastuszak I, O'Donnell J, Elbein AD. Identification of the GalNAc kinase amino acid sequence. J Biol Chem. 1996 Sep 27;271(39):23653-6. PMID:8798585
↑ Thoden JB, Holden HM. The molecular architecture of human N-acetylgalactosamine kinase. J Biol Chem. 2005 Sep 23;280(38):32784-91. Epub 2005 Jul 8. PMID:16006554 doi:10.1074/jbc.M505730200

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OCA

[1] Pastuszak I, O'Donnell J, Elbein AD. Identification of the GalNAc kinase amino acid sequence. J Biol Chem. 1996 Sep 27;271(39):23653-6. PMID:8798585

[2] Thoden JB, Holden HM. The molecular architecture of human N-acetylgalactosamine kinase. J Biol Chem. 2005 Sep 23;280(38):32784-91. Epub 2005 Jul 8. PMID:16006554 doi:10.1074/jbc.M505730200

[1]

[2]

2a2c

x-ray structure of human N-acetyl galactosamine kinase complexed with Mg-ADP and N-acetyl galactosamine 1-phosphatex-ray structure of human N-acetyl galactosamine kinase complexed with Mg-ADP and N-acetyl galactosamine 1-phosphate

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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2a2c

x-ray structure of human N-acetyl galactosamine kinase complexed with Mg-ADP and N-acetyl galactosamine 1-phosphatex-ray structure of human N-acetyl galactosamine kinase complexed with Mg-ADP and N-acetyl galactosamine 1-phosphate

Structural highlights

Function

Evolutionary Conservation

See Also

References

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