2a28

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Atomic-resolution crystal structure of the second SH3 domain of yeast Bzz1 determined from a pseudomerohedrally twinned crystalAtomic-resolution crystal structure of the second SH3 domain of yeast Bzz1 determined from a pseudomerohedrally twinned crystal

Structural highlights

2a28 is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.07Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BZZ1_YEAST Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Soulard A, Lechler T, Spiridonov V, Shevchenko A, Shevchenko A, Li R, Winsor B. Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. Mol Cell Biol. 2002 Nov;22(22):7889-906. PMID:12391157
  2. ↑ Soulard A, Friant S, Fitterer C, Orange C, Kaneva G, Mirey G, Winsor B. The WASP/Las17p-interacting protein Bzz1p functions with Myo5p in an early stage of endocytosis. Protoplasma. 2005 Oct;226(1-2):89-101. Epub 2005 Oct 20. PMID:16231105 doi:http://dx.doi.org/10.1007/s00709-005-0108-4

2a28, resolution 1.07Å

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OCA
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