1zze

X-ray Structure of NADPH-dependent Carbonyl Reductase from Sporobolomyces salmonicolorX-ray Structure of NADPH-dependent Carbonyl Reductase from Sporobolomyces salmonicolor

Structural highlights

1zze is a 2 chain structure with sequence from Sporidiobolus salmonicolor. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALD2_SPOSA Catalyzes the asymmetric reduction of o-substituted aliphatic and aromatic aldehydes and ketones to an S-enantiomer. Reduces ethyl 4-chloro-3-oxobutanoate to ethyl (S)-4-chloro-3-hydroxybutanoate.^[1] [REFERENCE:2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Kita K, Fukura T, Nakase KI, Okamoto K, Yanase H, Kataoka M, Shimizu S. Cloning, overexpression, and mutagenesis of the Sporobolomyces salmonicolor AKU4429 gene encoding a new aldehyde reductase, which catalyzes the stereoselective reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (S)-4-chloro-3-hydroxybutanoate. Appl Environ Microbiol. 1999 Dec;65(12):5207-11. PMID:10583966

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OCA

[1] Kita K, Fukura T, Nakase KI, Okamoto K, Yanase H, Kataoka M, Shimizu S. Cloning, overexpression, and mutagenesis of the Sporobolomyces salmonicolor AKU4429 gene encoding a new aldehyde reductase, which catalyzes the stereoselective reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (S)-4-chloro-3-hydroxybutanoate. Appl Environ Microbiol. 1999 Dec;65(12):5207-11. PMID:10583966

[1]

1zze

X-ray Structure of NADPH-dependent Carbonyl Reductase from Sporobolomyces salmonicolorX-ray Structure of NADPH-dependent Carbonyl Reductase from Sporobolomyces salmonicolor

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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1zze

X-ray Structure of NADPH-dependent Carbonyl Reductase from Sporobolomyces salmonicolorX-ray Structure of NADPH-dependent Carbonyl Reductase from Sporobolomyces salmonicolor

Structural highlights

Function

Evolutionary Conservation

See Also

References

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