1zjs

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

STRUCTURE OF I-SUPERFAMILY CONOTOXIN VITX FROM CONUS VIRGOSTRUCTURE OF I-SUPERFAMILY CONOTOXIN VITX FROM CONUS VIRGO

Structural highlights For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, PDBsum, ProSAT Publication Abstract from PubMed I-superfamily conotoxins have four-disulfide bonds with cysteine arrangement C-C-CC-CC-C-C, and they inhibit or modify ion channels of nerve cells. They have been characterized only recently and are relatively less well studied compared to other superfamily conotoxins. We have detected selective and sensitive sequence pattern for I-superfamily conotoxins. The availability of sequence pattern should be useful in protein family classification and functional annotation. We have built by homology modeling, a theoretical structural 3D model of ViTx from Conus virgo, a typical member of I-superfamily conotoxins. The modeling was based on the available 3D structure of Janus-atracotoxin-Hv1c of Janus-atracotoxin family whose members have been suggested as possible biopesticides. A study comparing the theoretically modeled structure of ViTx, with experimentally determined structures of other toxins, which share functional similarity with ViTx, reveals the crucial role of C-terminal region of ViTx in blocking therapeutically important voltage-gated potassium channels. I-superfamily conotoxins: sequence and structure analysis.,Mondal S, Vijayan R, Shichina K, Babu RM, Ramakumar S In Silico Biol. 2005;5(5-6):557-71. PMID:16268797 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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