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Re-engineering topology of the homodimeric ROP protein into a single-chain 4-helix bundleRe-engineering topology of the homodimeric ROP protein into a single-chain 4-helix bundle
Structural highlights
FunctionROP_ECOLX Regulates plasmid DNA replication by modulating the initiation of transcription of the primer RNA precursor. Processing of the precursor of the primer, RNAII, is inhibited by hydrogen bonding of RNAII to its complementary sequence in RNAI. ROP increases the affinity of RNAI for RNAII and thus decreases the rate of replication initiation events. See Also |
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