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Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

A PLAUSIBLE MODEL OF FULL-LENGTH INTEGRASEDNA COMPLEXA PLAUSIBLE MODEL OF FULL-LENGTH INTEGRASEDNA COMPLEX

Structural highlights For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, PDBsum, ProSAT Publication Abstract from PubMed A model of the full-length HIV-1 integrase dimer was constructed assembling the experimentally determined structures of the single domains. Subsequently, the three-domain protein-viral DNA complex was generated for the first time through an automated docking algorithm, obtained modifying the ESCHER program, a well-known method for protein-protein docking. A detailed study of the contacts established with DNA by the enzyme revealed that the predicted model reproduced the results of mutagenesis and cross-linking experiments, confirming the validity of our docking approach in predicting the base specificity in the DNA-protein interaction. Analysis of the full-length integrase-DNA complex by a modified approach for DNA docking.,De Luca L, Pedretti A, Vistoli G, Barreca ML, Villa L, Monforte P, Chimirri A Biochem Biophys Res Commun. 2003 Oct 31;310(4):1083-8. PMID:14559226 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

spinqualitylabelsall models 1wkn Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image