1qtt

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SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1

Structural highlights

1qtt is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

MTCP1_HUMAN Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.

Function

MTCP1_HUMAN Enhances the phosphorylation and activation of AKT1 and AKT2.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. Laine J, Kunstle G, Obata T, Sha M, Noguchi M. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell. 2000 Aug;6(2):395-407. PMID:10983986
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