1pl7

Human Sorbitol Dehydrogenase (apo)Human Sorbitol Dehydrogenase (apo)

Structural highlights

1pl7 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DHSO_HUMAN Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity).^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Frenette G, Thabet M, Sullivan R. Polyol pathway in human epididymis and semen. J Androl. 2006 Mar-Apr;27(2):233-9. Epub 2005 Nov 8. PMID:16278369 doi:http://dx.doi.org/10.2164/jandrol.05108

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OCA

[1] Frenette G, Thabet M, Sullivan R. Polyol pathway in human epididymis and semen. J Androl. 2006 Mar-Apr;27(2):233-9. Epub 2005 Nov 8. PMID:16278369 doi:http://dx.doi.org/10.2164/jandrol.05108

[1]

1pl7

Human Sorbitol Dehydrogenase (apo)Human Sorbitol Dehydrogenase (apo)

Structural highlights

Function

Evolutionary Conservation

References

Contents

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1pl7

Human Sorbitol Dehydrogenase (apo)Human Sorbitol Dehydrogenase (apo)

Structural highlights

Function

Evolutionary Conservation

References

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