1p4x

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Crystal structure of SarS protein from Staphylococcus AureusCrystal structure of SarS protein from Staphylococcus Aureus

Structural highlights

1p4x is a 1 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SARS_STAA8 Transcriptional regulator that controls expression of some virulence factors in a cell density-dependent manner. Acts as an activator of the gene encoding protein A (spa). Negatively regulates the expression of alpha-hemolysin (hla).[1] [2]

References

  1. ↑ Tegmark K, Karlsson A, Arvidson S. Identification and characterization of SarH1, a new global regulator of virulence gene expression in Staphylococcus aureus. Mol Microbiol. 2000 Jul;37(2):398-409. PMID:10931334 doi:10.1046/j.1365-2958.2000.02003.x
  2. ↑ Cheung AL, Schmidt K, Bateman B, Manna AC. SarS, a SarA homolog repressible by agr, is an activator of protein A synthesis in Staphylococcus aureus. Infect Immun. 2001 Apr;69(4):2448-55. PMID:11254606 doi:10.1128/IAI.69.4.2448-2455.2001

1p4x, resolution 2.20Å

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OCA
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