1cz3

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DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMADIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA

Structural highlights

1cz3 is a 2 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DYR_THEMA Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1cz3, resolution 2.10Å

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OCA