1agn

X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASEX-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE

Structural highlights 1agn is a 4 chain structure with sequence from Homo sapiens. The January 2001 RCSB PDB Molecule of the Month feature on Alcohol Dehydrogenase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2001_1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3Å Ligands: , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ADH7_HUMAN Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Alcohol dehydrogenase 3D structures

spinqualitylabelsall models 1agn, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image