1dys
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ENDOGLUCANASE CEL6B FROM HUMICOLA INSOLENS
OverviewOverview
Cellulases are traditionally classified as either endoglucanases or, cellobiohydrolases on the basis of their respective catalytic activities, on crystalline cellulose, which is generally hydrolysed more efficiently, only by the cellobiohydrolases. On the basis of the Trichoderma reesei, cellobiohydrolase II structure, it was proposed that the active-site, tunnel of cellobiohydrolases permitted the processive hydrolysis of, cellulose, whereas the corresponding endoglucanases would display open, active-site clefts [Rouvinen, Bergfors, Teeri, Knowles and Jones (1990), Science 249, 380-386]. Glycoside hydrolase family 6 contains both, cellobiohydrolases and endoglucanases. The structure of the catalytic core, of the family 6 endoglucanase Cel6B from Humicola insolens has been solved, by ... [(full description)]
About this StructureAbout this Structure
1DYS is a [Single protein] structure of sequence from [Humicola insolens]. Active as [Hydrolase], with EC number [3.2.1.4]. Structure known Active Sites: CIA and CIB. Full crystallographic information is available from [OCA].
ReferenceReference
Structure and function of Humicola insolens family 6 cellulases: structure of the endoglucanase, Cel6B, at 1.6 A resolution., Davies GJ, Brzozowski AM, Dauter M, Varrot A, Schulein M, Biochem J. 2000 May 15;348 Pt 1:201-7. PMID:10794732
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