1c38
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SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMEDIATE
OverviewOverview
Potassium can stabilize the formation of chair- or edge-type quadruplex, DNA structures and appears to be the only naturally occurring cation that, can do so. As quadruplex DNAs may be important in the structure of, telomere, centromere, triplet repeat and other DNAs, information about the, details of the potassium-quadruplex DNA interactions are of interest. The, structures of the 1:1 and the fully saturated, 2:1, potassium-DNA, complexes of d(GGTTGGTGTGGTTGG) have been determined using the combination, of experimental NMR results and restrained molecular dynamics simulations., The refined structures have been used to model the interactions at the, potassium binding sites. Comparison of the 1:1 and 2:1 potassium:DNA, structures indicates how potassium binding can determine the folding, pattern of the DNA. In each binding site potassium interacts with the, carbonyl oxygens of both the loop thymine residues and the guanine, residues of the adjacent quartet.
About this StructureAbout this Structure
1C38 is a Protein complex structure of sequences from [1] with K as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA., Marathias VM, Bolton PH, Nucleic Acids Res. 2000 May 1;28(9):1969-77. PMID:10756199
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