1ih4
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Multi-Conformation Crystal Structure of GGm5CGCC
OverviewOverview
The transition between B- and A-DNA was first observed nearly 50 years, ago. We have now mapped this transformation through a set of, single-crystal structures of the sequence d(GGCGCC)2, with various, intermediates being trapped by methylating or brominating the cytosine, bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary, B-nucleotides serving as a distinct transition intermediate. The details, of each step in the conversion of B- to A-DNA are thus revealed at the, atomic level, placing intermediates for this and other sequences in the, context of a common pathway.
About this StructureAbout this Structure
1IH4 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
ReferenceReference
A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969
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