2v6e
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PROTELOMERASE TELK COMPLEXED WITH SUBSTRATE DNA
OverviewOverview
The termini of linear chromosomes are protected by specialized DNA, structures known as telomeres that also facilitate the complete, replication of DNA ends. The simplest type of telomere is a covalently, closed DNA hairpin structure found in linear chromosomes of prokaryotes, and viruses. Bidirectional replication of a chromosome with hairpin, telomeres produces a catenated circular dimer that is subsequently, resolved into unit-length chromosomes by a dedicated DNA, cleavage-rejoining enzyme known as a hairpin telomere resolvase, (protelomerase). Here we report a crystal structure of the protelomerase, TelK from Klebsiella oxytoca phage varphiKO2, in complex with the, palindromic target DNA. The structure shows the TelK dimer destabilizes, base pairing interactions to promote the ... [(full description)]
About this StructureAbout this Structure
2V6E is a [Single protein] structure of sequence from [Klebsiella phage phiko2] with VO4 as [ligand]. Full crystallographic information is available from [OCA].
ReferenceReference
An Interlocked Dimer of the Protelomerase TelK Distorts DNA Structure for the Formation of Hairpin Telomeres., Aihara H, Huang WM, Ellenberger T, Mol Cell. 2007 Sep 21;27(6):901-13. PMID:17889664
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