2nvy
RNA Polymerase II form II in 150 mM Mn+2
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OverviewOverview
New structures of RNA polymerase II (pol II) transcribing complexes reveal, a likely key to transcription. The trigger loop swings beneath a correct, nucleoside triphosphate (NTP) in the nucleotide addition site, closing off, the active center and forming an extensive network of interactions with, the NTP base, sugar, phosphates, and additional pol II residues. A, histidine side chain in the trigger loop, precisely positioned by these, interactions, may literally "trigger" phosphodiester bond formation., Recognition and catalysis are thus coupled, ensuring the fidelity of, transcription.
About this StructureAbout this Structure
2NVY is a Protein complex structure of sequences from Saccharomyces cerevisiae with ZN and MN as ligands. Active as DNA-directed RNA polymerase, with EC number 2.7.7.6 Full crystallographic information is available from OCA.
ReferenceReference
Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis., Wang D, Bushnell DA, Westover KD, Kaplan CD, Kornberg RD, Cell. 2006 Dec 1;127(5):941-54. PMID:17129781
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