Triose Phosphate Isomerase

Triose Phosphate Isomerase

File:TPIstructure.jpg prions.com

Template:STRUCTURE 1tim

OverviewOverview

(TPI or TIM) which catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate, an essential process in the glycolytic pathway.

MechanismMechanism

TPI catalyzes the transfer of a hydrogen atom from carbon 1 to carbon 2, an intramolecular oxidation-reduction. This isomerization of a ketose to an aldose proceeds through an enediol intermediate.<Biochemistry 6th Edition>

Acid Base CatalysisAcid Base Catalysis

File:TPI mechanism.jpg

Diagram .<ref name= "web.virginia.edu" [1]

References For further information on Triose Phosphate IsomeraseReferences For further information on Triose Phosphate Isomerase

[[2]] [[3]]

Triosephosphate isomerase deficiency

Berg, Jeremy M. Sryer, Lubert. Tymoczko, John L. Biochemistry: 6th Edition. W.H Freedman and Company (2007)