Triose Phosphate Isomerase
Triose Phosphate Isomerase
OverviewOverview
(TPI or TIM) which catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate, an essential process in the glycolytic pathway.
MechanismMechanism
TPI catalyzes the transfer of a hydrogen atom from carbon 1 to carbon 2, an intramolecular oxidation-reduction. This isomerization of a ketose to an aldose proceeds through an enediol intermediate.<Biochemistry 6th Edition>
Acid Base CatalysisAcid Base Catalysis
Diagram .<ref name= "web.virginia.edu" [1]
Structure & FunctionStructure & Function
DiseaseDisease
Triose Phosphate Isomerase DeficiencyTriose Phosphate Isomerase Deficiency
See AlsoSee Also
References For further information on Triose Phosphate IsomeraseReferences For further information on Triose Phosphate Isomerase
Berg, Jeremy M. Sryer, Lubert. Tymoczko, John L. Biochemistry: 6th Edition. W.H Freedman and Company (2007)