Triose Phosphate Isomerase
Triose Phosphate Isomerase (TPI or TIM) which catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate, an essential process in the glycolytic pathway.
MechanismMechanism
Acid Base CatalysisAcid Base Catalysis
Diagram .<ref name= "web.virginia.edu" [1]
Structure & Function
Disease
= Triose Phosphate Isomerase Deficiency
Triose Phosphate Isomease Deficiency is a rare (less then 100 cases worldwide), autosomal recessive disorder first described in 1965.<Schneider, Arthur S.; William N. Valentine, Hattori M, H. L. Heins Jr (1965). "Hereditary Hemolytic Anemia with Triosephosphate Isomerase Deficiency". New England Journal of Medicine 272: 229–35> Symptoms include haemolytic anaemia, cardiomyopathy, an increased susceptibility to infections, severe neurological dysfunctions, and, often times, death in early childhood.