Sandbox2 Eric Martz

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In MHC Class I (mouse and human) Q226 is part of the binding site for CD8^[1]. Regarding the alpha chain (A) in human MHC 1akj, the authors state:

A flexible loop of the alpha3 domain (residues 223-229) is clamped between the complementarity-determining region (CDR)-like loops of the two CD8 subunits in the classic manner of an antibody-antigen interaction ....

Hydrogen bonds between CD8 and the alpha chain of HLA-A2 that involve this loop are (from Table 2^[1]):

CD8:D  T30.OG1 : T225.O       HLA-A2:A  2.7 Å
CD8:E   S34.OG   : Q226.NE2                     3.0

Server	Sequences	Q226*	APD
2VAA chain A
ConSurf-DB	144	4	1.72

ReferencesReferences

↑ ^1.0 ^1.1 Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen BK. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Nature. 1997 Jun 5;387(6633):630-4. PMID:9177355 doi:http://dx.doi.org/10.1038/42523

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Eric Martz

[gao-1] 1.0 ^1.1 Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen BK. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Nature. 1997 Jun 5;387(6633):630-4. PMID:9177355 doi:http://dx.doi.org/10.1038/42523

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