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GlucokinaseGlucokinase

--Student 07:51, 4 March 2009 (IST)Niva Ran and Tinuke Adeyemi

General InformationGeneral Information

Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. Its structures also revealed an allosteric site through which small molecules may modulate the kinetic properties of the enzyme. This finding provided the mechanistic basis for activation of glucokinase as a potential therapeutic approach for treating type 2 diabetes mellitus.

StructureStructure

1v4s, resolution 2.30Å ()

Ligands:

, ,

Activity:

Hexokinase, with EC number 2.7.1.1

Related:

1v4t

Structural annotation:
Resources:	InterPro : Ipr001312 Pfam : PF00349, PF03727 SCOP : d1v4sa2, d1v4sa1 UniProt : P35557

Functional annotation:
Biological process:	glucose homeostasis detection of glucose positive regulation of glycogen biosynthetic process glucose metabolic process glycolysis negative regulation of gluconeogenesis positive regulation of insulin secretion
Molecular function:	glucokinase activity kinase activity nucleotide binding hexokinase activity transferase activity ATP binding protein binding glucose binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

ReferenceReference

http://www.proteopedia.org/wiki/index.php/1v4s

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