2h3d
|
Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide
OverviewOverview
Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide, mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic, pathway and is required for SirT1 activity in vivo. Nampt has also been, presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal, structure of Nampt in the presence and absence of NMN shows that Nampt is, a dimeric type II phosphoribosyltransferase and provides insights into the, enzymatic mechanism.
About this StructureAbout this Structure
2H3D is a Single protein structure of sequence from Mus musculus with NMN as ligand. Active as Nicotinamide phosphoribosyltransferase, with EC number 2.4.2.12 Full crystallographic information is available from OCA.
ReferenceReference
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme., Wang T, Zhang X, Bheda P, Revollo JR, Imai S, Wolberger C, Nat Struct Mol Biol. 2006 Jul;13(7):661-2. Epub 2006 Jun 18. PMID:16783373
Page seeded by OCA on Wed Nov 21 11:31:45 2007