2gc8

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Template:STRUCTURE 2gc8

File:2gc8.png

Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b PolymeraseStructure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase

Template:ABSTRACT PUBMED 16722622

About this StructureAbout this Structure

2GC8 is a 2 chains structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS. Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site. J Med Chem. 2006 Jun 1;49(11):3052-5. PMID:16722622 doi:10.1021/jm060168g

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OCA

[1] Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS. Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site. J Med Chem. 2006 Jun 1;49(11):3052-5. PMID:16722622 doi:10.1021/jm060168g

[xtra 1]