2qc8

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Template:ABSTRACT PUBMED 18005987

File:2qc8.png

2qc8, resolution 2.60Å ()

Ligands:

, , ,

Gene:

GLUL, GLNS (Homo sapiens)

Activity:

Glutamate--ammonia ligase, with EC number 6.3.1.2

Related:

2ojw

Structural annotation:
Resources:	InterPro : Ipr014746, Ipr008147, Ipr008146 Pfam : PF00120, PF03951 UniProt : P15104

Functional annotation:
Cellular component:	cytoplasm
Biological process:	nitrogen compound metabolic process glutamine biosynthetic process regulation of neurotransmitter levels
Molecular function:	ligase activity glutamate-ammonia ligase activity catalytic activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphateCrystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate

About this StructureAbout this Structure

2QC8 is a 10 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Krajewski WW, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T, Mowbray SL. Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design. J Mol Biol. 2008 Jan 4;375(1):217-28. Epub 2007 Oct 17. PMID:18005987 doi:10.1016/j.jmb.2007.10.029

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OCA

[1] Krajewski WW, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T, Mowbray SL. Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design. J Mol Biol. 2008 Jan 4;375(1):217-28. Epub 2007 Oct 17. PMID:18005987 doi:10.1016/j.jmb.2007.10.029

[xtra 1]