1urw

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File:1urw.png

Template:STRUCTURE 1urw

CDK2 IN COMPLEX WITH AN IMIDAZO[1,2-B]PYRIDAZINECDK2 IN COMPLEX WITH AN IMIDAZO[1,2-B]PYRIDAZINE

Template:ABSTRACT PUBMED 15081018

About this StructureAbout this Structure

1URW is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}^{[xtra 2]}

↑ Byth KF, Cooper N, Culshaw JD, Heaton DW, Oakes SE, Minshull CA, Norman RA, Pauptit RA, Tucker JA, Breed J, Pannifer A, Rowsell S, Stanway JJ, Valentine AL, Thomas AP. Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett. 2004 May 3;14(9):2249-52. PMID:15081018 doi:10.1016/j.bmcl.2004.02.008
↑ Schulze-Gahmen U, De Bondt HL, Kim SH. High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design. J Med Chem. 1996 Nov 8;39(23):4540-6. PMID:8917641 doi:10.1021/jm960402a

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OCA

[1] Byth KF, Cooper N, Culshaw JD, Heaton DW, Oakes SE, Minshull CA, Norman RA, Pauptit RA, Tucker JA, Breed J, Pannifer A, Rowsell S, Stanway JJ, Valentine AL, Thomas AP. Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett. 2004 May 3;14(9):2249-52. PMID:15081018 doi:10.1016/j.bmcl.2004.02.008

[2] Schulze-Gahmen U, De Bondt HL, Kim SH. High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design. J Med Chem. 1996 Nov 8;39(23):4540-6. PMID:8917641 doi:10.1021/jm960402a

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