2cas
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THE CANINE PARVOVIRUS EMPTY CAPSID STRUCTURE
OverviewOverview
The structure of empty canine parvovirus capsids shows that residues 37 to, the carboxy-terminal residue 584 (VP2 numbering) are ordered in each of, the 60 subunits. The central structural motif of each subunit is the, eight-stranded antiparallel beta-barrel that has been found in many other, virus structures. Five beta-hairpin turns form a beta-cylindrical, structure at each icosahedral 5-fold axis. The N-terminal glycine-rich, sequence can be accommodated within this cylinder without excessive steric, hindrance, consistent with the electron density distribution. By far the, largest conformational differences between the full and empty virus were, found in the region where some ordered DNA has been observed to bind in, canine parvovirus full particles. Extensive interactions among 3-fold, related subunits indicate that a trimeric subunit might be a viral, assembly intermediate.
About this StructureAbout this Structure
2CAS is a Single protein structure of sequence from Canine parvovirus. Full crystallographic information is available from OCA.
ReferenceReference
The canine parvovirus empty capsid structure., Wu H, Rossmann MG, J Mol Biol. 1993 Sep 20;233(2):231-44. PMID:8377200
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