1vzv
STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE
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OverviewOverview
Varicella-zoster virus (VZV), an alpha-herpes virus, is the causative, agent of chickenpox, shingles, and postherpetic neuralgia. The, three-dimensional crystal structure of the serine protease from VZV has, been determined at 3.0-A resolution. The VZV protease is essential for the, life cycle of the virus and is a potential target for therapeutic, intervention. The structure reveals an overall fold that is similar to, that recently reported for the serine protease from cytomegalovirus (CMV), a herpes virus of the beta subfamily. The VZV protease structure provides, further evidence to support the finding that herpes virus proteases have a, fold and active site distinct from other serine proteases. The VZV, protease catalytic triad consists of a serine and two histidines. The, distal ... [(full description)]
About this StructureAbout this Structure
1VZV is a [Single protein] structure of sequence from [Varicella-zoster virus (isolate 40a2)]. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of varicella-zoster virus protease., Qiu X, Janson CA, Culp JS, Richardson SB, Debouck C, Smith WW, Abdel-Meguid SS, Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2874-9. PMID:9096314
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