2ahm
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Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer
OverviewOverview
Coronavirus replication and transcription machinery involves multiple, virus-encoded nonstructural proteins (nsp). We report the crystal, structure of the hexadecameric nsp7-nsp8 supercomplex from the severe, acute respiratory syndrome coronavirus at 2.4-angstroms resolution. nsp8, has a novel 'golf-club' fold with two conformations. The supercomplex is a, unique hollow, cylinder-like structure assembled from eight copies of nsp8, and held tightly together by eight copies of nsp7. With an internal, diameter of approximately 30 angstroms, the central channel has dimensions, and positive electrostatic properties favorable for nucleic acid binding, implying that its role is to confer processivity on RNA-dependent RNA, polymerase.
About this StructureAbout this Structure
2AHM is a Protein complex structure of sequences from Human sars coronavirus with SO4 and GOL as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer., Zhai Y, Sun F, Li X, Pang H, Xu X, Bartlam M, Rao Z, Nat Struct Mol Biol. 2005 Nov;12(11):980-6. PMID:16228002
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