2a9i
|
Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain
OverviewOverview
IL-1R-associated kinase (IRAK) 4 is an essential component of innate, immunity. IRAK-4 deficiency in mice and humans results in severe, impairment of IL-1 and TLR signaling. We have solved the crystal structure, for the death domain of Mus musculus IRAK-4 to 1.7 A resolution. This is, the first glimpse of the structural details of a mammalian IRAK family, member. The crystal structure reveals a six-helical bundle with a, prominent loop, which among IRAKs and Pelle, a Drosophila homologue, is, unique to IRAK-4. This highly structured loop contained between helices, two and three, comprises an 11-aa stretch. Although innate immune domain, recognition is thought to be very similar between Drosophila and mammals, this structural component points to a drastic difference. This structure, can be used as a framework for future mutation and deletion studies and, potential drug design.
About this StructureAbout this Structure
2A9I is a Single protein structure of sequence from Mus musculus with MN as ligand. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
ReferenceReference
Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling., Lasker MV, Gajjar MM, Nair SK, J Immunol. 2005 Oct 1;175(7):4175-9. PMID:16177054
Page seeded by OCA on Wed Nov 21 08:00:11 2007