1oht
PEPTIDOGLYCAN RECOGNITION PROTEIN-LB
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OverviewOverview
The family of peptidoglycan recognition proteins (PGRPs) are associated, with the recognition of the peptidoglycan of microbes and subsequent, activation of signaling pathways for immune response. Here the crystal, structure of Drosophila PGRP-LB is determined at a resolution of 2.0 A and, shows an active-site cleft with a zinc cage. Poor conservation of surface, residues at the cleft predicts a widely varying individual specificity of, PGRPs for molecular patterns on microbial cell walls. At the back of this, cleft is a putatively conserved distinctive groove. The location and, mainly hydrophobic nature of the groove indicate that the back face serves, for subsequent signaling after clustering of PGRP molecules by binding to, polymeric cell wall components.
About this StructureAbout this Structure
1OHT is a [Single protein] structure of sequence from [Drosophila melanogaster] with ZN, EDO and TLA as [ligands]. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster., Kim MS, Byun M, Oh BH, Nat Immunol. 2003 Aug;4(8):787-93. Epub 2003 Jul 6. PMID:12845326
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