1yo4
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Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein
OverviewOverview
The SARS related Coronavirus genome contains a variety of novel accessory, genes. One of these, called ORF7a or ORF8, code for a protein, known as, 7a, U122 or X4. We set out to determine the three-dimensional structure of, the soluble ectodomain of this type-I transmembrane protein by nuclear, magnetic resonance spectroscopy. The fold of the protein is the first, member of a further variation of the immunoglobulin like beta-sandwich, fold. Because X4 does not reveal significant sequence homologies to, proteins in the data bases, we carried out a structure based similarity, search for proteins with known function. High structural similarity to Dl, domains of ICAM-1 and ICAM-2, and common features in amino acid sequence, between X4 and ICAM-1, suggest X4 to possess binding activity for the, alpha(L) integrin I domain of LFA-1. Further, based on this structure, based prediction, potential functions of X4 in virus replication and, pathogenesis are discussed.
About this StructureAbout this Structure
1YO4 is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains., Hanel K, Stangler T, Stoldt M, Willbold D, J Biomed Sci. 2006 May;13(3):281-93. Epub 2005 Nov 23. PMID:16328780
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