2nwp

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Template:STRUCTURE 2nwp

File:2nwp.png

Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase IIStructural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II

Template:ABSTRACT PUBMED 17330962

DiseaseDisease

Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[611492]

About this StructureAbout this Structure

2NWP is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Fisher SZ, Tu C, Bhatt D, Govindasamy L, Agbandje-McKenna M, McKenna R, Silverman DN. Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II. Biochemistry. 2007 Mar 27;46(12):3803-13. Epub 2007 Mar 2. PMID:17330962 doi:10.1021/bi602620k

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OCA

[1] Fisher SZ, Tu C, Bhatt D, Govindasamy L, Agbandje-McKenna M, McKenna R, Silverman DN. Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II. Biochemistry. 2007 Mar 27;46(12):3803-13. Epub 2007 Mar 2. PMID:17330962 doi:10.1021/bi602620k

[xtra 1]