1x9t
The crystal structure of human adenovirus 2 penton base in complex with an ad2 N-terminal fibre peptide
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OverviewOverview
The adenovirus penton, a noncovalent complex of the pentameric penton base, and trimeric fiber proteins, comprises the vertices of the adenovirus, capsid and contains all necessary components for viral attachment and, internalization. The 3.3 A resolution crystal structure of human, adenovirus 2 (hAd2) penton base shows that the monomer has a basal, jellyroll domain and a distal irregular domain formed by two long, insertions, a similar topology to the adenovirus hexon. The Arg-Gly-Asp, (RGD) motif, required for interactions with cellular integrins, occurs on, a flexible surface loop. The complex of penton base with bound N-terminal, fiber peptide, determined at 3.5 A resolution, shows that the universal, fiber motif FNPVYPY binds at the interface of adjacent penton base, monomers and results in a localized structural rearrangement in the, insertion domain of the penton base. These results give insight into the, structure and assembly of the adenovirus capsid and will be of use for, gene-therapy applications.
About this StructureAbout this Structure
1X9T is a Single protein structure of sequence from Human adenovirus 2 with C15 as ligand. Full crystallographic information is available from OCA.
ReferenceReference
The structure of the human adenovirus 2 penton., Zubieta C, Schoehn G, Chroboczek J, Cusack S, Mol Cell. 2005 Jan 7;17(1):121-35. PMID:15629723
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