3e62

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Template:STRUCTURE 3e62

File:3e62.png

Fragment based discovery of JAK-2 inhibitorsFragment based discovery of JAK-2 inhibitors

Template:ABSTRACT PUBMED 19019674

DiseaseDisease

Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[147796], Myelofibrosis, idiopathic OMIM:[147796], Myeloproliferative disorder with erythrocytosis OMIM:[147796], Polycythemia vera OMIM:[147796], Thrombocythemia, essential OMIM:[147796], Budd-Chiari syndrome OMIM:[147796]

About this StructureAbout this Structure

3E62 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Fragment-based discovery of JAK-2 inhibitors., Antonysamy S, Hirst G, Park F, Sprengeler P, Stappenbeck F, Steensma R, Wilson M, Wong M, Bioorg Med Chem Lett. 2009 Jan 1;19(1):279-82. Epub 2008 Aug 22. PMID:19019674

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