3drr

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Template:STRUCTURE 3drr

File:3drr.png

HIV reverse transcriptase Y181C mutant in complex with inhibitor R8eHIV reverse transcriptase Y181C mutant in complex with inhibitor R8e

Template:ABSTRACT PUBMED 18826204

About this StructureAbout this Structure

3DRR is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

ReferenceReference

Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5 -chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses., Tucker TJ, Sisko JT, Tynebor RM, Williams TM, Felock PJ, Flynn JA, Lai MT, Liang Y, McGaughey G, Liu M, Miller M, Moyer G, Munshi V, Perlow-Poehnelt R, Prasad S, Reid JC, Sanchez R, Torrent M, Vacca JP, Wan BL, Yan Y, J Med Chem. 2008 Oct 1. PMID:18826204

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