1urw

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Template:STRUCTURE 1urw

File:1urw.png

CDK2 IN COMPLEX WITH AN IMIDAZO[1,2-B]PYRIDAZINECDK2 IN COMPLEX WITH AN IMIDAZO[1,2-B]PYRIDAZINE

Template:ABSTRACT PUBMED 15081018

About this StructureAbout this Structure

1URW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors., Byth KF, Cooper N, Culshaw JD, Heaton DW, Oakes SE, Minshull CA, Norman RA, Pauptit RA, Tucker JA, Breed J, Pannifer A, Rowsell S, Stanway JJ, Valentine AL, Thomas AP, Bioorg Med Chem Lett. 2004 May 3;14(9):2249-52. PMID:15081018

High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design., Schulze-Gahmen U, De Bondt HL, Kim SH, J Med Chem. 1996 Nov 8;39(23):4540-6. PMID:8917641

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