1ptq
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PROTEIN KINASE C DELTA CYS2 DOMAIN
OverviewOverview
Protein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes, that associate with membranes and are activated by diacylglycerol or, tumor-promoting agonists such as phorbol esters. The structure of the, second activator-binding domain of PKC delta has been determined in, complex with phorbol 13-acetate, which binds in a groove between two, pulled-apart beta strands at the tip of the domain. The C3, C4, and C20, phorbol oxygens form hydrogen bonds with main-chain groups whose, orientation is controlled by a set of highly conserved residues. Phorbol, binding caps the groove and forms a contiguous hydrophobic surface, covering one-third of the domain, explaining how the activator promotes, insertion of PKC into membranes.
About this StructureAbout this Structure
1PTQ is a Single protein structure of sequence from Mus musculus with ZN as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester., Zhang G, Kazanietz MG, Blumberg PM, Hurley JH, Cell. 1995 Jun 16;81(6):917-24. PMID:7781068
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