1pdu
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Ligand-binding domain of Drosophila orphan nuclear receptor DHR38
OverviewOverview
Ecdysteroid pulses trigger the major developmental transitions during the, Drosophila life cycle. These hormonal responses are thought to be mediated, by the ecdysteroid receptor (EcR) and its heterodimeric partner, Ultraspiracle (USP). We provide evidence for a second ecdysteroid, signaling pathway mediated by DHR38, the Drosophila ortholog of the, mammalian NGFI-B subfamily of orphan nuclear receptors. DHR38 also, heterodimerizes with USP, and this complex responds to a distinct class of, ecdysteroids in a manner that is independent of EcR. This response is, unusual in that it does not involve direct binding of ecdysteroids to, either DHR38 or USP. X-ray crystallographic analysis of DHR38 reveals the, absence of both a classic ligand binding pocket and coactivator binding, site, features that seem to be common to all NGFI-B subfamily members., Taken together, these data reveal the existence of a separate structural, class of nuclear receptors that is conserved from fly to humans.
About this StructureAbout this Structure
1PDU is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
ReferenceReference
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway., Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ, Cell. 2003 Jun 13;113(6):731-42. PMID:12809604
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