1nz9
|
Solution Structure of the N-utilisation substance G (NusG) C-terminal (NGC) domain from Thermus thermophilus
OverviewOverview
NusG is an essential bacterial protein modulator of transcriptional, elongation and termination events, and interacts directly with RNA, polymerase and Rho protein. Found also in Archaea, NusG shows stretches of, sequence similarity to the eukaryotic transcription elongation factor, Spt5. Herein, the three-dimensional solution structure of the bacterial, NusG from Thermus thermophilus, which shows 43% amino acid sequence, similarity to the Escherichia coli NusG, is described, and a survey of, NusG and Spt5 amino acid sequences is presented. Although there is a clear, evolutionary and functional relationship between these proteins, it is, evident from the structural, sequence, and biochemical data that their, binding specificities to both nucleic acids and other proteins differ.
About this StructureAbout this Structure
1NZ9 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.
ReferenceReference
Structural and sequence comparisons arising from the solution structure of the transcription elongation factor NusG from Thermus thermophilus., Reay P, Yamasaki K, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S, Proteins. 2004 Jul 1;56(1):40-51. PMID:15162485
Page seeded by OCA on Tue Nov 20 22:40:55 2007
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Single protein
- Thermus thermophilus
- Kuramitsu, S.
- RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.
- Reay, P.
- Shirouzu, M.
- Terada, T.
- Yamasaki, K.
- Yokoyama, S.
- Antitermination
- Riken structural genomics/proteomics initiative
- Rsgi
- Structural genomics
- Termination
- Transcription elongation