1urr
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A NOVEL DROSOPHILA MELANOGASTER ACYLPHOSPHATASE (ACPDRO2)
OverviewOverview
Analysis of the Drosophila melanogaster EST database led to the discovery, and cloning of a novel acylphosphatase. The CG18505 gene coding for a new, enzyme (AcPDro2) is clearly distinct from the previously described, CG16870Acyp gene, which also codes for a D. melanogaster acylphosphatase, (AcPDro). The putative catalytic residues, together with residues held to, stabilize the acylphosphatase fold, are conserved in the two encoded, proteins. Crystals of AcPDro2, which belong to the trigonal space group, P3(1)21, with unit-cell parameters a = b = 45.8, c = 98.6 angstroms, gamma, = 120 degrees, allowed the solution of the protein structure by molecular, replacement and its refinement to 1.5 angstroms resolution. The AcPDro2, active-site structure is discussed.
About this StructureAbout this Structure
1URR is a [Single protein] structure of sequence from [Drosophila melanogaster] with GOL as [ligand]. Active as [[1]], with EC number [3.6.1.7]. Full crystallographic information is available from [OCA].
ReferenceReference
Three-dimensional structural characterization of a novel Drosophila melanogaster acylphosphatase., Zuccotti S, Rosano C, Ramazzotti M, Degl'Innocenti D, Stefani M, Manao G, Bolognesi M, Acta Crystallogr D Biol Crystallogr. 2004 Jun;60(Pt 6):1177-9. Epub 2004, May 21. PMID:15159593
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