1nes
STRUCTURE OF THE PRODUCT COMPLEX OF ACETYL-ALA-PRO-ALA WITH PORCINE PANCREATIC ELASTASE AT 1.65 ANGSTROMS RESOLUTION
|
OverviewOverview
A single crystal of porcine pancreatic elastase was mounted in a, thin-walled capillary and allowed to react with, acetyl-Ala-Pro-Ala-paranitroanalide. Diffraction data to 1.65 A resolution, were measured and the isomorphous structure was solved from the difference, Fourier map. The structure contains two surprises. Two molecules of the, product: acetyl-Ala-Pro-Ala molecule are bound in the extended binding, site. Both molecules are bound backwards with respect to the established, mode of peptide binding.
About this StructureAbout this Structure
1NES is a Single protein structure of sequence from Sus scrofa with CA, SO4 and ACE as ligands. Active as Pancreatic elastase, with EC number 3.4.21.36 Full crystallographic information is available from OCA.
ReferenceReference
Structure of the product complex of acetyl-Ala-Pro-Ala with porcine pancreatic elastase at 1.65 A resolution., Meyer EF Jr, Radhakrishnan R, Cole GM, Presta LG, J Mol Biol. 1986 Jun 5;189(3):533-9. PMID:3640831
Page seeded by OCA on Tue Nov 20 22:11:56 2007