1mix
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Crystal structure of a FERM domain of Talin
OverviewOverview
The binding of cytoplasmic proteins, such as talin, to the cytoplasmic, domains of integrin adhesion receptors mediates bidirectional signal, transduction. Here we report the crystal structure of the principal, integrin binding and activating fragment of talin, alone and in complex, with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel, variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand, interaction that may be a prototype for FERM domain recognition of, transmembrane receptors. In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the, integrin beta 3 tail, providing structural paradigms for integrin linkage, to the cell interior.
About this StructureAbout this Structure
1MIX is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.
ReferenceReference
Structural determinants of integrin recognition by talin., Garcia-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC, Mol Cell. 2003 Jan;11(1):49-58. PMID:12535520
Page seeded by OCA on Tue Nov 20 21:26:39 2007