2va5
X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 8CX-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 8C
Template:ABSTRACT PUBMED 17985862
About this StructureAbout this Structure
2VA5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency., Edwards PD, Albert JS, Sylvester M, Aharony D, Andisik D, Callaghan O, Campbell JB, Carr RA, Chessari G, Congreve M, Frederickson M, Folmer RH, Geschwindner S, Koether G, Kolmodin K, Krumrine J, Mauger RC, Murray CW, Olsson LL, Patel S, Spear N, Tian G, J Med Chem. 2007 Nov 29;50(24):5912-25. Epub 2007 Nov 7. PMID:17985862
Page seeded by OCA on Mon Jul 28 08:47:55 2008
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OCACategories:
- Pages with broken file links
- Homo sapiens
- Memapsin 2
- Single protein
- Aharony, D.
- Albert, J S.
- Andisik, D.
- Callaghan, O.
- Campbell, J B.
- Carr, R A.
- Chessari, G.
- Congreve, M.
- Edwards, P D.
- Folmer, R H.A.
- Frederickson, M.
- Geschwindner, S.
- Koether, G.
- Kolmodin, K.
- Krumrine, J.
- Mauger, R C.
- Murray, C W.
- Olsson, L.
- Patel, S.
- Spear, N.
- Sylvester, M.
- Tian, G.
- Alternative splicing
- Alzheimer's disease
- Aspartic protease
- Aspartyl protease
- Base
- Beta-secretase
- Glycoprotein
- Hydrolase
- Membrane
- Protease
- Transmembrane
- Zymogen